Arthur P. Chou M.D., Ph.D.

Education & Training

Published Works

• Tumor­ Suppressive miR148a Is Silenced by CpG Island Hypermethylation in IDH1-Mutant Gliomas — 2014
  Li S, Chowdhury R, Liu F, Chou AP, Li T, Mody RR, Lou JJ, Chen W, Reiss J, Soto H, Prins R, Liau LM, Mischel PS, Nghiemphu PL, Yong WH, Cloughesy TF, Lai A. Tumor­Suppressive miR148a Is Silen
• Deferred use of bevacizumab for recurrent glioblastoma is not associated with diminished efficacy — 2014
  Piccioni DE, Selfridge J, Mody RR, Chowdhury R, Li S, Lalezare S, Wawrzynski J, Quan J, Zurayk M, Chou AP, Sanchez DE, Liau LM, Ellingson BM, Pope WB, Nghiemphu PL, Green RM, Wang HJ, Yong WH
• Prediction of GBM outcome using combined analysis of MGMT protein expression and promoter methylation — 2013
  Lalezari s·, Chou AP·, Tran A, Solis OE, Chen W, Carrillo JA, Selfridge J, Miller P, Mischel PS, Nghiemphu PL, Wang HJ, Elashoff RM, Liau LM, Cloughesy TF, Yong WH, Lai A. Prediction of GBM o
• Overexpression of isocitrate dehydrogenase 1 (IDH1) R132H mutant protein renders U87 glioma cells less malignant and more sensitive to radiation — 2013
  Lis·, Chou AP·, Chen W, Chen R, Deng Y, Phillips HS, Faull KF, Cloughesy TF, Liau LM, Lai A. Overexpression of isocitrate dehydrogenase 1 (IDH1) R132H mutant protein renders U87 glioma ce
• Identification of Retinal Binding Protein 1 (RBP1) Promoter Hypermethylation in IDH1/IDH2 Mutant Gliomas — 2012
  Chou AP·, Chowdhury R·, Lis·, Chen W, Kim AJ, Piccioni DE, Selfridge JM, Mody RR, Chang S, Lalezari S, Lin J, Sanchez DE, Wilson RW, Garrett MC, Harry B, Mottahedeh J, Nghiemphu PL, Kornblum
• Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy — 2012
  Pope WB, Prins RB, Thomas MA, Nagarajan R, Yen KE, Bittinger MA, Salamon N, Chou AP, Yong WH, Soto H, Wilson N, Driggers E, Jang HG, Su SM, Schenkein DP, Lai A, Cloughesy TF, Kornblum HI, Wu
• Mechanisms of rotenone-induced proteasome inhibition — 2010
  Chou AP, Li S, Fitzmaurice AG, Bronstein JM. Mechanisms of rotenone-induced proteasome inhibition. Neurotoxicology. 31, 367-372, 2010. doi:10.1016/j.neuro.2010.04.006
• In Silica Enhanced Restriction Enzyme Based Methylation Analysis of the Human Glioblastoma Genome Using Agilent 244K CpG Island Microarrays — 2010
  Tran A, Escovedo C, Migdall-Wilson J, Chou AP, Chen W, Cloughesy T, Nelson S, Lai A. In Silica Enhanced Restriction Enzyme Based Methylation Analysis of the Human Glioblastoma Genome Using Ag
• Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome — 2008
  Chou, AP, Maidment N, Klintenberg R, Casida JE, Li S, Fitzmaurice AG, Fernagut PO, Chesselet M-F, Bronstein JM. Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome
• Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease — 2006
  Wang XF, Li S, Chou AP, Bronstein JM. Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson's disease. Neurobiol Dis, 23(1 ): 198-205, 2006. doi:10.1016/j.nbd.2006
• Thermal Chemistry of C3Metallacycles on Pt(111) Surfaces — 2001
  Chrysostomou D, Chou A, Zaera F. Thermal Chemistry of C3Metallacycles on Pt(111) Surfaces. J. Phys. Chem. B, 105: 5968-5978, 2001. doi:10.1021/jp0105387
• Ab initio study of the intermolecular potential surface of He-NH3 — 1999
  Li ZR, Chou A, Tao F-M. Ab initio study of the intermolecular potential surface of He-NH3. Chem. Phys. Ltrs., 313(1-2): 313-320, 1999. doi:10.1016/S0009-2614(99)01083-0
• Density functional studies of the formation of nitrous acid from the reaction of nitrogen dioxide and water vapor — 1999
  Chou A, Li ZR, Tao F-M. Density functional studies of the formation of nitrous acid from the reaction of nitrogen dioxide and water vapor. J. Phys. Chem. A, 103(39): 7848-7855, 1999. doi: 10.

Professional Affiliations

• Primary Stroke Center at Garfield Medical Center
  Medical Director
• Allied Pacific IPA
  Medical Director

Honors & Awards

• UCLA Department of Neurosurgery Harold and Mimi Steinberg Resident Award — 2011
  Academic Excellence
• American Association of Neurological Surgeons Springer Journal of Neuro-Oncology Award — 2012
• American Brain Tumor Association Basic Research Fellowship — 2012